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Fat-dissolving injections

Lemon Bottle / Aqualyx / deoxycholic acid / Kybella / lipolysis shots · Cosmetic injectable (lipolysis)

Research reference only. Pepdex does not sell, supply or track this compound, and nothing here is guidance to use it — this page exists so the evidence and the risks are visible.

What it is

Injectables marketed to dissolve localized fat: one FDA-approved product exists (deoxycholic acid / Kybella, for under-chin fat, physician-administered), surrounded by unapproved "lipolysis solutions" — Lemon Bottle (a riboflavin/lecithin/bromelain mix) being the best-known.

What human evidence shows

Kybella has RCTs for one small anatomical area. Lemon Bottle and its cousins have no published controlled evidence at all — the viral before/afters are marketing, and the ingredient list does not contain an established lipolytic mechanism at cosmetic doses.

Risks

Kybella's own trials document swelling, nodules, numbness, and rare marginal-mandibular nerve injury — with a physician injecting. Unapproved injections add infection, scarring, tissue injury (necrosis case reports exist in the aesthetics literature), and total composition uncertainty.

Legal status

US: Kybella is prescription/physician-use. The FDA has warned that unapproved fat-dissolving injections are unapproved drugs and can be harmful — a product marketed to alter body structure is a drug regardless of "cosmetic" labeling.

Evidence base

Not auto-graded. This entry covers several different drugs, or a use the published research was never about, so no single letter honestly describes it. The reading below is real literature — read it against what this page says, not as a score.

Research (12)

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Where next

Every compound in the catalogThe full non-peptide index, with evidence grades.→The peptide indexInjectable peptides, half-lives and what trials used.→Spotting a scam vendorRed flags, COA checks and what traceability looks like.→