What are the side effects of Hexarelin?
The most commonly reported Hexarelin side effects are cortisol bump, prolactin bump, head-rush / flushing. Most are mild and tend to be dose dependent. It is generally avoided with active malignancy. Human clinical evidence for Hexarelin is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported Hexarelin side effects
- Cortisol bump
- Prolactin bump
- Head-rush / flushing
- Receptor desensitization with chronic use
Who should avoid it
- Active malignancy
- Pregnancy / nursing
Bloodwork worth tracking
- IGF-1 baseline + week 4
- Cortisol AM if running >2 weeks
- Prolactin
References
- Hexarelin and growth hormone secretion — Imbimbo BP et al., JCEM, 1994
- Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery — Broglio F et al., European Journal of Pharmacology, 2002
- Cardiac effects of hexarelin in hypopituitary adults — Bisi G et al., European Journal of Pharmacology, 1999
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.