Pepdexpepdex
My Stack
№ 025

Hexarelin

The hardest-hitting growth-hormone booster in this class. The most potent GH secretagogue, it gives a stronger pulse than Ipamorelin but with cortisol and prolactin bumps, so short cycles only.

GH-axis
Evidence: Limited

Hexarelin: The hardest-hitting growth-hormone booster in this class. The most potent GH secretagogue, it gives a stronger pulse than Ipamorelin but with cortisol and prolactin bumps, so short cycles only. Hexarelin is the most potent GH secretagogue, more aggressive than Ipamorelin.

FDA ⓘ
Not approved
WADA
Banned
Typical dose
100-200 mcg sub-q
Half-life ⓘ
~70 minutes
Route ⓘ
Subcutaneous
Schedule
1-2x daily
In plain English

Hexarelin is the most potent GH secretagogue, more aggressive than Ipamorelin. Comes with stronger side effects (cortisol bump, prolactin) and faster receptor desensitization. Short cycles only, not a daily-driver.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Banned (S2)
Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Experienced users wanting maximum GH-pulse strength briefly
  • →Recovery focused short cycles

What to expect

  1. Week 1

    Strong GH pulse felt as deep sleep. Some flushing.

  2. Week 4

    Cycle endpoint. Stop and switch back to Ipamorelin/CJC for maintenance.

  3. Week 8

    Off-cycle. Receptors recovering before next short cycle.

Looking at Hexarelin? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for Hexarelin.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

    A free account saves your stack; membership adds the stack-aware AI Coach.

    Create free account →

How it works (mechanism)

Hexapeptide GH secretagogue, more potent than Ipamorelin or GHRP-2 at the GHS-R1a receptor. The strong activation drives stronger GH pulses but also bumps cortisol and prolactin and causes faster receptor desensitization.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01Cortisol bump
02Prolactin bump
03Head-rush / flushing
04Receptor desensitization with chronic use

When NOT to use

  • ⚠Active malignancy
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • IGF-1 baseline + week 4
  • • Cortisol AM if running >2 weeks
  • • Prolactin

Common mistakes

  • • Running longer than 4 weeks (rapid receptor desensitization)
  • • Treating it like a daily-driver
  • • Skipping the prolactin/cortisol bloodwork

Drug & supplement interactions

  • ⚠Cortisol and prolactin elevation, caution with prolactin-sensitive contexts
  • ⚠Receptor desensitizes within 4 weeks, interactions matter less because cycles are short

Community patterns

Members only
Free, no account needed

New to Hexarelin? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if Hexarelin changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about Hexarelin or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

Get the Coach, $7.99/mo →

Frequently asked

What is Hexarelin?+
Hexarelin is the most potent GH secretagogue, more aggressive than Ipamorelin. Comes with stronger side effects (cortisol bump, prolactin) and faster receptor desensitization. Short cycles only, not a daily-driver.
Is Hexarelin FDA approved?+
Not FDA approved.
Is Hexarelin legal?+
Hexarelin is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is Hexarelin banned by WADA?+
Hexarelin is on the WADA prohibited list under Banned (S2).
Are you still natty after taking Hexarelin?+
No. Hexarelin is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Hexarelin?+
Not prescribed in conventional medicine.
What's the typical dose of Hexarelin?+
100-200 mcg sub-q, 1-2x daily, for max 4 weeks.
What are the side effects of Hexarelin?+
Common side effects include: Cortisol bump; Prolactin bump; Head-rush / flushing; Receptor desensitization with chronic use. Less common effects and full safety details are on the entry page.
How long until Hexarelin starts working?+
Strong GH pulse felt as deep sleep. Some flushing.
What can you stack with Hexarelin?+
Common pairings: CJC-1295 (no-DAC) for amplified pulse; Switch to Ipamorelin for the next cycle to avoid desensitization. Full stacking protocol and timing on the entry page.
Where do people get Hexarelin?+
Hexarelin is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.
Hexarelin vs Ipamorelin, which is better?+
Hexarelin vs Ipamorelin: strongest GH secretagogue vs cleanest one. Cortisol and prolactin trade-offs. Full head-to-head comparison: https://pepdex.co/compare/hexarelin-vs-ipamorelin

Head-to-head with Hexarelin

Compare
Hexarelin vs Ipamorelin →

More in GH-axis

№ 021
HGH (Somatropin)

Recombinant human growth hormone, the protein itself, not a peptide that nudges your body to make more. Highest legal-risk compound in this catalog.

№ 011
MK-677 (Ibutamoren)

Oral ghrelin mimetic. Bumps GH and IGF-1 without injections. Strong appetite stimulation is the trade-off.

№ 006
Ipamorelin

Bumps your natural growth-hormone pulses without hitting cortisol or prolactin. A selective GH secretagogue.

№ 007
CJC-1295 (no DAC)

Pairs with Ipamorelin to amplify your natural growth-hormone pulses. A GHRH analog whose 'no-DAC' version stays short-acting on purpose.