How long does Liraglutide (Saxenda / Victoza) take to work?
In the first week of Liraglutide (Saxenda / Victoza), appetite drops. Mild nausea common. Around week 4, first titration step. ~2-4 lb down typical. By week 8, cumulative loss 5-10 lb for most users. Response varies between people, this is the commonly reported pattern, not a guarantee.
Week by week
- Week 1: Appetite drops. Mild nausea common.
- Week 4: First titration step. ~2-4 lb down typical.
- Week 8: Cumulative loss 5-10 lb for most users.
References
- A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management (SCALE Obesity) — Pi-Sunyer X et al., NEJM, 2015
- Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes (LEADER) — Marso SP et al., New England Journal of Medicine, 2016
- Victoza (liraglutide) — Drugs@FDA approval record (ApplNo 022341) — FDA, Drugs@FDA
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.