How is MOTS-c administered?
This describes how MOTS-c is typically administered in clinical and research references, not a self-administration guide. The usual route is Subcutaneous, on a 3x weekly schedule, generally over 4-6 weeks. Specific dosing is individual and beyond general information, and human evidence for MOTS-c is limited.
Administration at a glance (reference data)
- Route: Subcutaneous
- Schedule: 3x weekly
- Cycle length: 4-6 weeks
- Half-life: ~2 hours
References
- MOTS-c: a mitochondrial-derived peptide regulating holistic metabolism — Lee C et al., Trends Endocrinol Metab, 2020
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis — Reynolds JC, Lai RW, Woodhead JST, et al. (Lee C, senior author) — Nature Communications, 2021
- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases — Kong BS, Lee C, Cho YM — Diabetes & Metabolism Journal, 2023
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.