What is the half-life of MOTS-c?
MOTS-c has a reported half life of ~2 hours, given subcutaneous. That is why it is typically dosed 3x weekly. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~2 hours
- Route: Subcutaneous
- Typical schedule: 3x weekly
- Cycle length: 4-6 weeks
References
- MOTS-c: a mitochondrial-derived peptide regulating holistic metabolism — Lee C et al., Trends Endocrinol Metab, 2020
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis — Reynolds JC, Lai RW, Woodhead JST, et al. (Lee C, senior author) — Nature Communications, 2021
- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases — Kong BS, Lee C, Cho YM — Diabetes & Metabolism Journal, 2023
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.