What is the half-life of Petrelintide?
Petrelintide has a reported half life of ~10 days (acylated/lipidated), given subcutaneous. That is why it is typically dosed once weekly. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~10 days (acylated/lipidated)
- Route: Subcutaneous
- Typical schedule: Once weekly
- Cycle length: Trial protocols
References
- Zealand Pharma announces positive Phase 2 results for petrelintide, an amylin analog with potential to redefine the weight management experience for people living with overweight and obesity — Zealand Pharma (press release via GlobeNewswire), March 5, 2026
- Roche announces positive Phase II results for petrelintide, an amylin analog developed for people living with overweight and obesity — Roche (press release), March 5, 2026
- A Randomized, Double-Blind, Phase 2 Trial of Once-Weekly Petrelintide Compared With Placebo in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2) — ClinicalTrials.gov, NCT06926842 (Sponsor: Zealand Pharma)
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.