What is the half-life of PT-141 (Bremelanotide)?
PT-141 (Bremelanotide) has a reported half life of ~2 hours, given subcutaneous. That is why it is typically dosed at least 45 min before activity, max 1x per 24h. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~2 hours
- Route: Subcutaneous
- Typical schedule: at least 45 min before activity, max 1x per 24h
- Cycle length: Use as needed, not daily
References
- Bremelanotide for HSDD in premenopausal women — Kingsberg SA et al., Obstet Gynecol, 2019
- Prespecified and Integrated Subgroup Analyses from the RECONNECT Phase 3 Studies of Bremelanotide — Simon JA, Kingsberg SA, Portman D, et al.; Journal of Women's Health; 2022
- Responder Analyses from a Phase 2b Dose-Ranging Study of Bremelanotide — Althof S, Derogatis LR, Greenberg S, et al.; Journal of Sexual Medicine; 2019
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.