How long does Setmelanotide (Imcivree) take to work?
In the first week of Setmelanotide (Imcivree), appetite drops noticeably in monogenic-obesity patients. Skin pigmentation begins to shift. Around week 4, weight loss tracking established. By week 8, cumulative weight loss; pigmentation visible. Response varies between people, this is the commonly reported pattern, not a guarantee.
Week by week
- Week 1: Appetite drops noticeably in monogenic-obesity patients. Skin pigmentation begins to shift.
- Week 4: Weight loss tracking established.
- Week 8: Cumulative weight loss; pigmentation visible.
References
- Setmelanotide for Obesity due to LEPR or POMC deficiency — Clément K et al., Lancet Diabetes Endocrinol, 2020
- Efficacy and safety of setmelanotide in patients with Bardet-Biedl syndrome and Alström syndrome: a phase 3 trial — Haqq AM et al., The Lancet Diabetes & Endocrinology, 2022
- Imcivree (setmelanotide) — Drugs@FDA approval record (ApplNo 213793) — FDA, Drugs@FDA
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.