Apigenin
Sleep
Chamomile flavonoid popularised by podcast sleep stacks.
What the evidence says
Essentially no human trials of isolated apigenin for sleep. The evidence is preclinical plus chamomile-tea studies — treat popularity and evidence as separate things.
What studies used
50 mg is the commonly promoted dose. Before bed.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Evidence base
established literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
This letter measures how much human research exists, not whether it works for you — the tier above (Anecdotal) is the read on quality.
Research (12)
- Apigenin: a natural molecule at the intersection of sleep and agingFront Nutr · 2024
- Apigenin's Therapeutic Potential Against Viral InfectionFront Biosci (Landmark Ed) · 2023
- Apigenin as an anticancer agentPhytother Res · 2020
- Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cellsRedox Biol · 2021
- Apigenin and its dermatological applications: A comprehensive reviewPhytochemistry · 2022
- The Anticancer Potential of Apigenin Via ImmunoregulationCurr Pharm Des · 2021
- The synthesis and bioactivity of apigenin derivativesFitoterapia · 2024
- Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanismsClin Exp Pharmacol Physiol · 2023
- Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and CancerInt J Mol Sci · 2023
- Natural Flavonoid Apigenin, an Effective Agent Against Nervous System CancersMol Neurobiol · 2024
- Apigenin Self-Assembled Collagen Biomatrix for Reprogramming the Obese Wound Microenvironment for Its Management and RepairACS Appl Bio Mater · 2024
- Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal modelsCrit Rev Oncol Hematol · 2022
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