CoQ10
Ubiquinol · Longevity
Mitochondrial cofactor, best studied in statin users and heart failure.
What the evidence says
Decent human evidence in heart failure and for statin-associated muscle symptoms. Benefit in healthy young adults is not established.
What studies used
100–300 mg daily. With a fatty meal.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Evidence base
established literature
Large human evidence base: several phase 3 or 4 trial reports, plus multiple meta-analyses or systematic reviews.
This letter measures how much human research exists, not whether it works for you — the tier above (Moderate) is the read on quality.
Research (12)
- The Effect of CoQ10 supplementation on ART treatment and oocyte quality in older womenHum Fertil (Camb) · 2023
- The role of CoQ10 in embryonic developmentJ Assist Reprod Genet · 2024
- Efficacy of CoQ10 as supplementation for migraine: A meta-analysisActa Neurol Scand · 2019
- CoQ10 a super-vitamin: review on application and biosynthesis3 Biotech · 2018
- Clinical applications of coenzyme Q10Front Biosci (Landmark Ed) · 2014
- CoQ10 deficiency diseases in adultsMitochondrion · 2007
- Disorders of Human Coenzyme Q10 Metabolism: An OverviewInt J Mol Sci · 2020
- Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokineticsFree Radic Res · 2006
- A Review of the Potential Role of CoQ10 in the Treatment of Hepatocellular CarcinomaBiochem Genet · 2024
- Comparison of Coenzyme Q10 (Ubiquinone) and Reduced Coenzyme Q10 (Ubiquinol) as Supplement to Prevent Cardiovascular Disease and Reduce Cardiovascular MortalityCurr Cardiol Rep · 2023
- Human CoQ10 deficienciesBiofactors · 2008
- CoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 MiceFront Biosci (Landmark Ed) · 2022
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