L-glutamine
Gut
Amino acid promoted for intestinal lining repair.
What the evidence says
Real evidence in clinical settings (burns, critical illness, some IBS subgroups). Evidence for "leaky gut" in otherwise healthy people is not there.
What studies used
5 g daily is common; gut trials use more. Any time.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Evidence base
established literature
Large human evidence base: several phase 3 or 4 trial reports, plus multiple meta-analyses or systematic reviews.
This letter measures how much human research exists, not whether it works for you — the tier above (Limited) is the read on quality.
Research (12)
- L-Glutamine2012
- L-glutamine for sickle cell disease: Knight or pawn?Exp Biol Med (Maywood) · 2020
- L-glutamine for sickle cell disease: more than reducing redoxAnn Hematol · 2022
- L-Glutamine-, peptidyl- and protein-glutaminases: structural features and applications in the food industryWorld J Microbiol Biotechnol · 2022
- l-Glutamine for sickle cell anemia: more questions than answersBlood · 2018
- L-glutamine sensitizes Gram-positive-resistant bacteria to gentamicin killingMicrobiol Spectr · 2023
- An L-Glutamine Transporter Isoform for Neurogenesis Facilitated by L-TheanineNeurochem Res · 2017
- Dissecting L-glutamine metabolism in acute myeloid leukemia: single-cell insights and therapeutic implicationsJ Transl Med · 2024
- L-Glutamine in sickle cell diseaseDrugs Today (Barc) · 2020
- The Emerging Role of l-Glutamine in Cardiovascular Health and DiseaseNutrients · 2019
- L-Glutamine is better for treatment than prevention in exhaustive exerciseFront Physiol · 2023
- The vaso-occlusive pain crisis in sickle cell disease: Definition, pathophysiology, and managementEur J Haematol · 2020
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