NMN / NR
NAD+ precursors · Longevity
NAD+ precursors sold on a very large promise built on a very small human base.
What the evidence says
Human trials reliably show blood NAD+ rises. What is NOT shown is that the rise produces the ageing outcomes the marketing implies. The gap between those two facts is where the entire category lives.
What studies used
250–1,000 mg daily in trials. Morning.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Evidence base
established literature
Strong human evidence: either a phase 3 or 4 trial report alongside review-level evidence, or ten or more randomised controlled trial reports.
This letter measures how much human research exists, not whether it works for you — the tier above (Limited) is the read on quality.
Research (12)
- The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an UpdateAdv Nutr · 2023
- Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenScience · 2021
- NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to HealthCurr Nutr Rep · 2023
- Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concernsJ Adv Res · 2022
- Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in MiceCell Metab · 2016
- Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD(+) synthesis via enterohepatic circulationSci Adv · 2025
- NAD+ and sirtuins in aging and diseaseTrends Cell Biol · 2014
- Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future DirectionsJ Gerontol A Biol Sci Med Sci · 2023
- Regulation of and challenges in targeting NAD(+) metabolismNat Rev Mol Cell Biol · 2024
- NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NRCell Metab · 2018
- β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic miceRedox Biol · 2023
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo EvidenceCell Metab · 2018
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