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Comparison

Ipamorelin vs Tesamorelin

Ipamorelin vs Tesamorelin: ghrelin mimetic vs GHRH analog. Two different paths to a higher GH pulse.

The verdict

Both raise GH but from different angles. Ipamorelin is a clean ghrelin-mimetic secretagogue, gentle and selective, popular as an everyday GH-axis peptide. Tesamorelin is a GHRH analog that's FDA-approved and known specifically for cutting visceral fat. If your goal is general recovery and a soft GH bump, Ipamorelin. If you're targeting belly/visceral fat and want the compound with actual approval behind it, Tesamorelin. They also pair well, since one mimics ghrelin and the other mimics GHRH.

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Ipamorelin
GH-axisEvidence: Limited

Ipamorelin gently nudges your body to release more of its own growth hormone, without the side effect baggage of injecting actual HGH. People run it for sleep, recovery, and slow body-comp shifts. Tiny doses, multiple times a day.

Onset
65
Documentation
75
Side intensity
64
Popularity
75
013
Tesamorelin
GH-axisEvidence: Strong

Tesamorelin is an FDA-approved GH-axis peptide that specifically targets visceral fat, the deep belly fat around organs. Daily injection. Slow burn, but the visceral fat reduction is well-documented.

Onset
65
Documentation
75
Side intensity
82
Popularity
55
Side-by-side
Field
Left
Right
Category
GH-axis
GH-axis
Half-life
~2 hours
~30 minutes
Route
Subcutaneous
Subcutaneous
Schedule
1-3x daily
Once daily
Cycle length
8-12 weeks on, 4 weeks off
12-26 weeks typical
Dose
100-300 mcg sub-q, 1-3x daily. Pre-bed dose is the most important pulse.
1-2 mg sub-q daily. Taken at the same time each day, ideally before bed.
FDA
Not FDA approved.
Approved as Egrifta, 2010, for HIV-associated lipodystrophy.
WADA
Banned (S2)
Banned (S2)
Natty?
Not natty
Not natty
Prescribed
Some anti-aging and longevity clinics prescribe via compounding pharmacies, off-label.
Yes for HIV indication. Off-label use outside that scope is common but not on-label.
Top side effects
Head-rush at injection; Mild hunger pulse 30 min post-dose; Tingling in hands rarely
Injection-site reaction; Fluid retention; Joint stiffness

Which one should you pick?

Pick Ipamorelin if users wanting gh benefits without the bloat / sides of hgh or sleep / recovery focused stacks.

Pick Tesamorelin if users targeting visceral (deep abdominal) fat specifically or older adults wanting gh-axis support without hgh.

AI Coach · free

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