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Comparison

MT-1 (Melanotan I) vs MT-2 (Melanotan II)

MT-1 vs MT-2 for tanning: side effect profile, libido effects, FDA status, and which is gentler.

The verdict

MT-1 is the more selective, cleaner option: it drives pigmentation with fewer of the extra effects people complain about. MT-2 tans harder and faster but is less selective, so it also hits libido and tends to bring rougher side effects like nausea and the libido spike. If you mainly want color with the least baggage, MT-1 is the gentler pick. People reach for MT-2 when they want the strongest pigment response and accept the messier profile that comes with it.

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MT-1 (Melanotan I)
PigmentEvidence: Strong

MT-1 mimics a hormone your body uses to make pigment in your skin. With sun or tanning-bed exposure, it gives you a darker tan from much less UV time. Cleaner side effect profile than the more popular MT-2.

Onset
85
Documentation
80
Side intensity
100
Popularity
55
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MT-2 (Melanotan II)
PigmentEvidence: Limited

MT-2 is the more potent (and rougher) sibling of MT-1. Stronger pigmentation but harder side effect profile, including unwanted libido effects. Most people who tried MT-2 first migrate to MT-1 for cleaner results.

Onset
85
Documentation
80
Side intensity
100
Popularity
75
Side-by-side
Field
Left
Right
Category
Pigment
Pigment
Half-life
~1 hour
~30 minutes
Route
Subcutaneous
Subcutaneous
Schedule
Daily loading → 1-2x weekly maintenance
Daily loading → 2-3x weekly maintenance
Cycle length
Loading 2-3 wks, then maintenance
Loading 1-2 wks, then maintenance
Dose
Loading: 250-500 mcg sub-q daily for 2-3 weeks. Maintenance: 250-500 mcg, 1-2x weekly. UV exposure required.
Loading: 250-500 mcg sub-q daily for 1-2 weeks. Maintenance: 250-500 mcg, 2-3x weekly. Pair with UV exposure.
FDA
Approved as Afamelanotide (Scenesse), 2019, for adults with erythropoietic protoporphyria.
Not FDA approved. Afamelanotide (MT-1) is the approved analog.
WADA
Not listed
Not listed
Natty?
Not natty
Not natty
Prescribed
Yes, Scenesse implant prescribed by dermatology / specialty providers for EPP. Off-label use for general pigmentation is outside the FDA approval.
Not prescribed in conventional medicine.
Top side effects
Nausea (first doses, usually fades); Facial flushing; Appetite suppression
Nausea (more pronounced than MT-1); Facial flushing; Spontaneous erections / increased libido

Which one should you pick?

Pick MT-1 (Melanotan I) if light-skinned users wanting baseline tan with less uv time or people who tried mt-2 and didn't tolerate the libido / nausea hit.

Pick MT-2 (Melanotan II) if users wanting deeper pigmentation than mt-1 delivers or people who specifically want the libido side effect.

AI Coach · free

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