What is the half-life of FGL?
FGL has a reported half life of Short (~hours), given subcutaneous or intranasal. That is why it is typically dosed daily. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: Short (~hours)
- Route: Subcutaneous or intranasal
- Typical schedule: Daily
- Cycle length: 2-4 weeks in animal protocols
References
- A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo — Skibo GG, Lushnikova IV, Voronin KY, Dmitrieva O, Novikova T, Klementiev B, Vaudano E, Berezin VA, Bock E. European Journal of Neuroscience, 2005
- The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner — Cox FF, Berezin V, Bock E, Lynch MA. Neuroscience, 2013
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
More on FGL
Last updated 2026-06-06.