What are the side effects of FGL?
The most commonly reported FGL side effects are limited human data, generally well tolerated in animal models. Most are mild and tend to be dose dependent. It is generally avoided with pregnancy / nursing. Human clinical evidence for FGL is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported FGL side effects
- Limited human data
- Generally well tolerated in animal models
Who should avoid it
- Pregnancy / nursing
- Anyone risk-averse to pre-clinical compounds
References
- A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo — Skibo GG, Lushnikova IV, Voronin KY, Dmitrieva O, Novikova T, Klementiev B, Vaudano E, Berezin VA, Bock E. European Journal of Neuroscience, 2005
- The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner — Cox FF, Berezin V, Bock E, Lynch MA. Neuroscience, 2013
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.