How does FGL work?
Synthetic peptide modeled on the FG-loop of NCAM (neural cell adhesion molecule). Binds FGFR1, activating cascades that support synapse formation and memory in animal models. In plain terms, FGL is studied for memory and learning in animal models. It's an FG-loop peptide modeled on the FG-loop region of NCAM (neural cell adhesion molecule). Mechanistic detail like this comes largely from preclinical and early research, the human picture is limited.
What people use it for
- Researchers studying NCAM-FGFR pathways
- Neuroplasticity research
- Educational reference, limited human data
References
- A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo — Skibo GG, Lushnikova IV, Voronin KY, Dmitrieva O, Novikova T, Klementiev B, Vaudano E, Berezin VA, Bock E. European Journal of Neuroscience, 2005
- The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner — Cox FF, Berezin V, Bock E, Lynch MA. Neuroscience, 2013
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.