What is the half-life of HCG (Human Chorionic Gonadotropin)?
HCG (Human Chorionic Gonadotropin) has a reported half life of ~24-36 hours sub-q, given subcutaneous or intramuscular. That is why it is typically dosed 2-3x weekly (low-dose alongside TRT) or daily (PCT restart). A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~24-36 hours sub-q
- Route: Subcutaneous or intramuscular
- Typical schedule: 2-3x weekly (low-dose alongside TRT) or daily (PCT restart)
- Cycle length: Continuous low-dose with TRT, or 4-6 week PCT pulse
References
- Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression — Coviello AD, Matsumoto AM, Bremner WJ, et al. — Journal of Clinical Endocrinology & Metabolism, 2005;90(5):2595-2602
- Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy — Hsieh TC, Pastuszak AW, Hwang K, Lipshultz LI — Journal of Urology, 2013;189(2):647-50
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.