What is the half-life of MK-677 (Ibutamoren)?
MK-677 (Ibutamoren) has a reported half life of ~24 hours, given oral. That is why it is typically dosed once daily. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~24 hours
- Route: Oral
- Typical schedule: Once daily
- Cycle length: 8-12 weeks on, 4 weeks off
References
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes — Nass R et al., Ann Intern Med, 2008
- Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure — Svensson J et al., Journal of Clinical Endocrinology & Metabolism, 1998
- LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report — Cardaci TD et al., Experimental Physiology, 2022
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.