Who should not take Octreotide (Sandostatin)?
Documented caution flags for Octreotide (Sandostatin) include hypersensitivity to octreotide and severe gallbladder disease. This is not exhaustive, and absence from this list is not a safety clearance. Anyone pregnant, nursing, or managing a serious medical condition should only consider it under a doctor's care, and safety data for Octreotide (Sandostatin) is limited.
Documented caution flags for Octreotide (Sandostatin)
- Hypersensitivity to octreotide
- Severe gallbladder disease
- Pregnancy / nursing (limited data)
Reported side effects to weigh
- GI (diarrhea, abdominal cramping, steatorrhea)
- Gallstones with chronic use
- Hyperglycemia (suppresses insulin)
- Bradycardia
References
- Octreotide therapy for acromegaly, long term outcome — Mercado M et al., JCEM, 2014
- Sandostatin LAR Depot (octreotide acetate) - FDA Label — FDA / DailyMed (Novartis Pharmaceuticals)
- Preoperative somatostatin analogues versus direct transsphenoidal surgery for newly-diagnosed acromegaly patients: a systematic review and meta-analysis using the GRADE system — Nunes VS et al., Pituitary, 2015
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.