How long does Octreotide (Sandostatin) take to work?
In the first week of Octreotide (Sandostatin), acromegaly users: GH and IGF-1 markers begin dropping. Carcinoid users: flushing and diarrhea reduce. Around week 4, hormone normalization in responders. By week 8, steady-state effect on tumor secretion in NET patients. Response varies between people, this is the commonly reported pattern, not a guarantee.
Week by week
- Week 1: Acromegaly users: GH and IGF-1 markers begin dropping. Carcinoid users: flushing and diarrhea reduce.
- Week 4: Hormone normalization in responders.
- Week 8: Steady-state effect on tumor secretion in NET patients.
References
- Octreotide therapy for acromegaly, long term outcome — Mercado M et al., JCEM, 2014
- Sandostatin LAR Depot (octreotide acetate) - FDA Label — FDA / DailyMed (Novartis Pharmaceuticals)
- Preoperative somatostatin analogues versus direct transsphenoidal surgery for newly-diagnosed acromegaly patients: a systematic review and meta-analysis using the GRADE system — Nunes VS et al., Pituitary, 2015
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.