What are the side effects of ACE-031 (ACVR2B-Fc)?
The most commonly reported ACE-031 (ACVR2B-Fc) side effects are epistaxis (nosebleeds), Phase 2 signal that halted development, telangiectasias (dilated capillaries near skin), headache. Most are mild and tend to be dose dependent. It is generally avoided with all, no current safe-use protocol exists. Human clinical evidence for ACE-031 (ACVR2B-Fc) is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported ACE-031 (ACVR2B-Fc) side effects
- Epistaxis (nosebleeds), Phase 2 signal that halted development
- Telangiectasias (dilated capillaries near skin)
- Headache
- Theoretical: cardiac and tendon issues with strong myostatin suppression
Who should avoid it
- All, no current safe-use protocol exists
- Pregnancy / nursing
- Active malignancy
Bloodwork worth tracking
- CBC if researching
- BUN / creatinine
References
- ACE-031 (soluble activin receptor IIB) increases muscle mass, Phase 1 in postmenopausal women — Attie KM et al., Muscle Nerve, 2013
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial — Campbell C, McMillan HJ, Mah JK, et al., Muscle & Nerve, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.