Who should not take ACE-031 (ACVR2B-Fc)?
Documented caution flags for ACE-031 (ACVR2B-Fc) include all, no current safe-use protocol exists and pregnancy / nursing. This is not exhaustive, and absence from this list is not a safety clearance. Anyone pregnant, nursing, or managing a serious medical condition should only consider it under a doctor's care, and safety data for ACE-031 (ACVR2B-Fc) is limited.
Documented caution flags for ACE-031 (ACVR2B-Fc)
- All, no current safe-use protocol exists
- Pregnancy / nursing
- Active malignancy
Reported side effects to weigh
- Epistaxis (nosebleeds), Phase 2 signal that halted development
- Telangiectasias (dilated capillaries near skin)
- Headache
- Theoretical: cardiac and tendon issues with strong myostatin suppression
References
- ACE-031 (soluble activin receptor IIB) increases muscle mass, Phase 1 in postmenopausal women — Attie KM et al., Muscle Nerve, 2013
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial — Campbell C, McMillan HJ, Mah JK, et al., Muscle & Nerve, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.