What is the half-life of ACE-031 (ACVR2B-Fc)?
ACE-031 (ACVR2B-Fc) has a reported half life of ~10-15 days, given subcutaneous. That is why it is typically dosed once weekly to once monthly in trials. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~10-15 days
- Route: Subcutaneous
- Typical schedule: Once weekly to once monthly in trials
- Cycle length: Historically tested in short courses
References
- ACE-031 (soluble activin receptor IIB) increases muscle mass, Phase 1 in postmenopausal women — Attie KM et al., Muscle Nerve, 2013
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial — Campbell C, McMillan HJ, Mah JK, et al., Muscle & Nerve, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.