What is ACE-031 (ACVR2B-Fc) used for?
ACE-031 (ACVR2B-Fc) is most commonly used for researchers studying myostatin pathway; educational reference, not for active use; followers of muscle-wasting drug development history. A muscle-building drug that blocks the body's brake on muscle, shelved over safety. A soluble activin receptor IIB fused to Fc that traps myostatin and related TGF-β ligands. Acceleron developed it; Phase 2 dosing was halted in 2011 over vascular safety signals (program permanently discontinued 2013). Human evidence for ACE-031 (ACVR2B-Fc) is limited, so these are the goals people pursue with it, not guaranteed outcomes.
What people use ACE-031 (ACVR2B-Fc) for
- Researchers studying myostatin pathway
- Educational reference, not for active use
- Followers of muscle-wasting drug development history
References
- ACE-031 (soluble activin receptor IIB) increases muscle mass, Phase 1 in postmenopausal women — Attie KM et al., Muscle Nerve, 2013
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial — Campbell C, McMillan HJ, Mah JK, et al., Muscle & Nerve, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.