What is the half-life of MT-2 (Melanotan II)?
MT-2 (Melanotan II) has a reported half life of ~30 minutes, given subcutaneous. That is why it is typically dosed daily loading → 2-3x weekly maintenance. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~30 minutes
- Route: Subcutaneous
- Typical schedule: Daily loading → 2-3x weekly maintenance
- Cycle length: Loading 1-2 wks, then maintenance
References
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study — Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME — Life Sciences, 1996;58(20):1777-84
- Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'? — Langan EA, Nie Z, Rhodes LE — British Journal of Dermatology, 2010;163(3):451-5
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.