How does PE-22-28 work?
TREK-1 channel inhibitor derived from spadin. TREK-1 is a potassium channel involved in mood regulation; blocking it produces fast antidepressant effects in animal models. In plain terms, PE-22-28 is synthetic peptide derived from spadin. TREK-1 channel inhibitor with rapid antidepressant effects in animal models. Pre-clinical. Mechanistic detail like this comes largely from preclinical and early research, the human picture is limited.
What people use it for
- Researchers studying TREK-1 pathways
- Antidepressant-mechanism research
- Educational reference, limited human safety data
References
- PE-22-28: a novel peptide for fast-acting antidepressant treatment — Mazella J et al., PLoS Biol, 2010
- Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity — Djillani A et al., Frontiers in Pharmacology, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.