Is PE-22-28 legal?
PE-22-28 is not FDA approved as a finished drug. For drug-tested athletes it is not on the WADA prohibited list. Not prescribed in conventional medicine.. Legal status depends on your country and changes over time. This reflects US status at the time of writing and is not legal or medical advice.
Regulatory status
- FDA: Not FDA approved. Pre-clinical.
- WADA: Not listed
- Prescription: Not prescribed in conventional medicine.
References
- PE-22-28: a novel peptide for fast-acting antidepressant treatment — Mazella J et al., PLoS Biol, 2010
- Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity — Djillani A et al., Frontiers in Pharmacology, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.