What is PE-22-28 used for?
PE-22-28 is most commonly used for researchers studying TREK-1 pathways; antidepressant-mechanism research; educational reference, limited human safety data. Synthetic peptide derived from spadin. TREK-1 channel inhibitor with rapid antidepressant effects in animal models. Pre-clinical. Human evidence for PE-22-28 is limited, so these are the goals people pursue with it, not guaranteed outcomes.
What people use PE-22-28 for
- Researchers studying TREK-1 pathways
- Antidepressant-mechanism research
- Educational reference, limited human safety data
References
- PE-22-28: a novel peptide for fast-acting antidepressant treatment — Mazella J et al., PLoS Biol, 2010
- Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity — Djillani A et al., Frontiers in Pharmacology, 2017
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.