pepdex
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№ 053

PE-22-28

Synthetic peptide derived from spadin. TREK-1 channel inhibitor with rapid antidepressant effects in animal models. Pre-clinical.

Nootropic
Evidence: Anecdotal
Half-life
Short (~hours)
Route
Subcutaneous or intranasal
Cycle
2-4 weeks
Schedule
Daily
In plain English

PE-22-28 is derived from spadin and blocks the TREK-1 channel. Animal-model antidepressant effects in days rather than weeks. Pre-clinical only — no human dose protocol, real interactions with SSRIs / SNRIs / heart-arrhythmia drugs.

Status & legality
Natty?
Not natty
FDA
Not approved

Not FDA approved. Pre-clinical.

Compounding
Not classified

Not formally categorized in the FDA bulks lists.

WADA
Not listed
Prescribed

Not prescribed in conventional medicine.

Who it's for

  • →Researchers studying TREK-1 pathways
  • →Antidepressant-mechanism research
  • →Educational reference — limited human safety data

What to expect

  1. Week 1

    Animal models show mood-task improvements rapidly.

  2. Week 4

    Cycle endpoint in pre-clinical protocols.

  3. Week 8

    No human long-term data.

How it works (mechanism)

TREK-1 channel inhibitor derived from spadin. TREK-1 is a potassium channel involved in mood regulation; blocking it produces fast antidepressant effects in animal models.

Dosing protocol

No standardized human dose. Animal models use per-kg dosing.

Stacks well with

Selank or Semax for compounded mood/anxiolytic effects (community pattern)
Standalone

Side effects

01Limited human safety data
02Theoretical effects on cardiac TREK-1 channels

When NOT to use

  • ⚠Active SSRI / SNRI / MAOI regimens
  • ⚠Cardiac arrhythmia history
  • ⚠Pregnancy / nursing

Common mistakes

  • • Stacking with other mood-active compounds
  • • Long cycles without safety data
  • • Treating animal-model dose as human dose

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is PE-22-28?+
PE-22-28 is derived from spadin and blocks the TREK-1 channel. Animal-model antidepressant effects in days rather than weeks. Pre-clinical only — no human dose protocol, real interactions with SSRIs / SNRIs / heart-arrhythmia drugs.
Is PE-22-28 FDA approved?+
Not FDA approved. Pre-clinical.
Is PE-22-28 banned by WADA?+
PE-22-28 is not currently on the WADA prohibited list.
Are you still natty after taking PE-22-28?+
No. PE-22-28 is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe PE-22-28?+
Not prescribed in conventional medicine.
What's the typical dose of PE-22-28?+
No standardized human dose. Animal models use per-kg dosing.
What are the side effects of PE-22-28?+
Common side effects include: Limited human safety data; Theoretical effects on cardiac TREK-1 channels. Less common effects and full safety details are on the entry page.
How long until PE-22-28 starts working?+
Animal models show mood-task improvements rapidly.

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