What are the side effects of Teduglutide (Gattex / Revestive)?
The most commonly reported Teduglutide (Gattex / Revestive) side effects are abdominal pain, nausea, fluid overload. Most are mild and tend to be dose dependent. It is generally avoided with active or suspected GI malignancy. Human clinical evidence for Teduglutide (Gattex / Revestive) is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported Teduglutide (Gattex / Revestive) side effects
- Abdominal pain
- Nausea
- Fluid overload
- Polyp / neoplasia risk (intestinal; requires colonoscopy surveillance, not a boxed warning)
- Injection-site reaction
Who should avoid it
- Active or suspected GI malignancy
- Pregnancy / nursing
Bloodwork worth tracking
- Colonoscopy at baseline + intervals
- ALT/AST
- Magnesium / electrolytes
References
- Teduglutide for the Treatment of Short Bowel Syndrome — Schwartz LK et al., NEJM, 2012
- Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure — Jeppesen PB, Pertkiewicz M, Messing B, et al. — Gastroenterology, 2012 (STEPS trial)
- GATTEX (teduglutide) for injection — FDA Prescribing Information — FDA / DailyMed (Takeda)
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.