What is the half-life of Teduglutide (Gattex / Revestive)?
Teduglutide (Gattex / Revestive) has a reported half life of ~2 hours, given subcutaneous. That is why it is typically dosed once daily. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~2 hours
- Route: Subcutaneous
- Typical schedule: Once daily
- Cycle length: Long-term in approved indication
References
- Teduglutide for the Treatment of Short Bowel Syndrome — Schwartz LK et al., NEJM, 2012
- Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure — Jeppesen PB, Pertkiewicz M, Messing B, et al. — Gastroenterology, 2012 (STEPS trial)
- GATTEX (teduglutide) for injection — FDA Prescribing Information — FDA / DailyMed (Takeda)
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.