Who should not take Teduglutide (Gattex / Revestive)?
Documented caution flags for Teduglutide (Gattex / Revestive) include active or suspected GI malignancy and pregnancy / nursing. This is not exhaustive, and absence from this list is not a safety clearance. Anyone pregnant, nursing, or managing a serious medical condition should only consider it under a doctor's care, and safety data for Teduglutide (Gattex / Revestive) is limited.
Documented caution flags for Teduglutide (Gattex / Revestive)
- Active or suspected GI malignancy
- Pregnancy / nursing
Reported side effects to weigh
- Abdominal pain
- Nausea
- Fluid overload
- Polyp / neoplasia risk (intestinal; requires colonoscopy surveillance, not a boxed warning)
References
- Teduglutide for the Treatment of Short Bowel Syndrome — Schwartz LK et al., NEJM, 2012
- Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure — Jeppesen PB, Pertkiewicz M, Messing B, et al. — Gastroenterology, 2012 (STEPS trial)
- GATTEX (teduglutide) for injection — FDA Prescribing Information — FDA / DailyMed (Takeda)
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-15.