What is the half-life of VIP (Vasoactive Intestinal Peptide)?
VIP (Vasoactive Intestinal Peptide) has a reported half life of ~2 minutes (rapid clearance), given intranasal (most common in clinical use). That is why it is typically dosed 4x daily intranasal. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~2 minutes (rapid clearance)
- Route: Intranasal (most common in clinical use)
- Typical schedule: 4x daily intranasal
- Cycle length: Months in CIRS protocol
References
- Vasoactive intestinal peptide (VIP) and inflammation, review — Delgado M & Ganea D, Amino Acids, 2013
- Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells — Sun X et al., World Journal of Gastroenterology, 2020
- Therapeutic Potential of Vasoactive Intestinal Peptide and its Derivative Stearyl-Norleucine-VIP in Inflammation-Induced Osteolysis — Eger M et al., Frontiers in Pharmacology, 2021
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.