Fisetin
Longevity
A strawberry flavonoid with striking mouse data and, so far, almost no human data.
What the evidence says
Fisetin extended lifespan in mice in the widely-cited Mayo Clinic work and was the most potent of the flavonoids in the senolytic screen that made it famous. Registered human trials exist and are running; results are not yet in hand. Everything currently sold rests on the mouse data plus the intermittent high-dose protocols those researchers used, which is extrapolation.
What studies used
Human trials are ongoing; no established supplemental dose exists. Published studies had not established a preferred timing.
Reported from published studies and product labelling — a record of what was used in research, not a recommendation. What is right for you is a conversation with a clinician.
Watch out for
- The human safety profile at the high intermittent doses people copy from mouse studies is not established
Evidence base
established literature
Real human evidence: randomised trial reports, or review-level evidence backed by at least one human trial report.
This letter measures how much human research exists, not whether it works for you — the tier above (Anecdotal) is the read on quality.
Research (12)
- Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseasesMech Ageing Dev · 2024
- Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosisActa Pharmacol Sin · 2024
- Fisetin: An anticancer perspectiveFood Sci Nutr · 2021
- Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signalingPhytomedicine · 2021
- Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescenceAging Cell · 2024
- Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI miceBiomed Pharmacother · 2020
- Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future TherapiesGlob Med Genet · 2023
- Fisetin: hormesis accounts for many of its chemoprotective effectsBiogerontology · 2025
- Role of Fisetin in Selected Malignant Neoplasms in WomenNutrients · 2023
- New Perspectives for FisetinFront Chem · 2019
- Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A ReviewInt J Mol Sci · 2023
- Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated reviewEur J Pharmacol · 2021
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