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№ 017

5-Amino-1MQ

An experimental fat-loss compound. An NNMT inhibitor that targets the enzyme driving metabolic stagnation in obesity, with animal and in-vitro data only and no published human results.

Fat Loss
Evidence: Anecdotal

5-Amino-1MQ: An experimental fat-loss compound. An NNMT inhibitor that targets the enzyme driving metabolic stagnation in obesity, with animal and in-vitro data only and no published human results. 5-Amino-1MQ blocks an enzyme called NNMT that gets overactive in obesity and stalls fat loss.

FDA ⓘ
Not approved
WADA
Not banned
Typical dose
50-150 mg orally
Half-life ⓘ
~6-8 hours
Route ⓘ
Oral
Schedule
Once or twice daily
In plain English

5-Amino-1MQ blocks an enzyme called NNMT that gets overactive in obesity and stalls fat loss. Oral capsule. Early human data is promising but limited, best treated as a metabolic adjunct, not a hero.

Status & legalityWhat do these mean? →
Natty? ⓘ
Not natty
FDA ⓘ
Not approved

Not FDA approved. In early human trials.

Compounding ⓘ
Not classified

Not formally categorized in the FDA bulks lists.

WADA ⓘ
Not listed
Prescribed ⓘ

Not prescribed in conventional medicine.

Who it's for

  • →Users in a stalled cut
  • →Plateau-broken stacks late in a diet phase
  • →People with sluggish metabolic markers

What to expect

  1. Week 1

    Subtle. Some users report energy bump.

  2. Week 4

    Body comp shifts in stacked-with-diet users.

  3. Week 8

    Plateau. Cycle off.

Looking at 5-Amino-1MQ? Your next 3 steps

  1. 1Work out your exact dose

    Vial size + BAC water turns into the exact units to draw for 5-Amino-1MQ.

    Open calculator →
  2. 2See what to stack & monitor

    The companion supplements and the bloodwork worth tracking on this kind of protocol.

    Bloodwork guide →
  3. 3Save it & ask the Coach

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How it works (mechanism)

Selective inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme overexpressed in obese adipose tissue. NNMT inhibition restores cellular methylation balance and unblocks fat metabolism.

Dosing protocol

Members only

Stacks well with

Members only

Side effects

01GI upset early
02Mild restlessness / energy at higher doses

When NOT to use

  • ⚠No long term human safety data, short cycles only
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • Liver enzymes baseline + week 8 (limited data, monitor)

Common mistakes

  • • Treating it as a primary fat-loss agent rather than a metabolic adjunct
  • • Running long cycles without the safety data to back it
  • • Expecting GLP-class results

Community patterns

Members only
Free, no account needed

New to 5-Amino-1MQ? Grab the starter checklist.

Drop your email and we'll send the one-page first-cycle starter checklist, plus a heads-up if 5-Amino-1MQ changes legal status. No account needed.

No spam. No selling your email. Just the checklist and the occasional reclassification alert.

AI Coach, live sample
Members only
is 250mcg of bpc enough for a knee injury?
For a knee, 250 mcg sub-q daily is the standard working dose and a solid place to start. The trick with BPC is consistency, give it weeks, not days. Inject close to the joint, run it 4-6 weeks, and don't drop below 200 mcg, it tends to stop cracking the threshold reliably down there. If it hasn't moved at all by week 3, that's when adding TB-500 earns its place.
how much bac water for a 10mg reta vial?
3 mL is the standard play for a 10 mg reta vial. That's 3,333 mcg/mL, clean unit math across the titration: 2 mg = 60 units, 4 mg = 120 units, 6 mg = 180 units on a 100-unit insulin syringe. Run 2 mL instead if you want fewer, more concentrated shots (5,000 mcg/mL, so 2 mg = 40 units). Since most people titrate up over ~12 weeks, 3 mL keeps the numbers cleanest.
what should i track on bloodwork for tirzepatide?
Lipid panel, ALT/AST (liver enzymes), and an A1C, baseline before you start then every 3 months. If you've got metabolic-syndrome history, add fasting glucose and insulin so you can actually watch insulin sensitivity improve. You don't need a big hormone panel for a GLP-1.

Ask the Coach anything about 5-Amino-1MQ or your own stack. This is it working.

Trained only on Pepdex content. Does the dose math, flags interactions, knows your stack. Won't push vendors, won't pretend to be a doctor.

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Frequently asked

What is 5-Amino-1MQ?+
5-Amino-1MQ blocks an enzyme called NNMT that gets overactive in obesity and stalls fat loss. Oral capsule. Early human data is promising but limited, best treated as a metabolic adjunct, not a hero.
Is 5-Amino-1MQ FDA approved?+
Not FDA approved. In early human trials.
Is 5-Amino-1MQ legal?+
5-Amino-1MQ is not FDA-approved. It is sold by compounding pharmacies (with a prescription) and as "research only" by peptide vendors. Possession is generally not criminalized but distribution without authorization may be. Verify local laws.
Is 5-Amino-1MQ banned by WADA?+
5-Amino-1MQ is not currently on the WADA prohibited list.
Are you still natty after taking 5-Amino-1MQ?+
No. 5-Amino-1MQ is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe 5-Amino-1MQ?+
Not prescribed in conventional medicine.
What's the typical dose of 5-Amino-1MQ?+
50-150 mg orally, daily (often split AM/PM).
What are the side effects of 5-Amino-1MQ?+
Common side effects include: GI upset early; Mild restlessness / energy at higher doses. Less common effects and full safety details are on the entry page.
How long until 5-Amino-1MQ starts working?+
Subtle. Some users report energy bump.
What can you stack with 5-Amino-1MQ?+
Common pairings: Tirzepatide / Retatrutide during cuts; AOD-9604 for fat-metabolism stacks. Full stacking protocol and timing on the entry page.
Where do people get 5-Amino-1MQ?+
5-Amino-1MQ is most commonly sold by research-only peptide vendors and by compounding pharmacies (the latter requires a prescription). Pepdex is not a vendor, see /coa for how to verify a Certificate of Analysis before buying from any source, and /guides/scam-vendor-spotting for vendor red flags.
5-Amino-1MQ vs MOTS-c, which is better?+
MOTS-c vs 5-Amino-1MQ: mitochondrial peptide vs NNMT inhibitor. Two pathways into metabolic flexibility. Full head-to-head comparison: https://pepdex.co/compare/mots-c-vs-5-amino-1mq

Head-to-head with 5-Amino-1MQ

Compare
5-Amino-1MQ vs MOTS-c →

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