What is the half-life of Mazdutide?
Mazdutide has a reported half life of ~8 days (dose-dependent), given subcutaneous. That is why it is typically dosed once weekly. A shorter half life means more frequent dosing to keep blood levels steady, a longer one lets you space doses further apart.
Quick facts
- Half-life: ~8 days (dose-dependent)
- Route: Subcutaneous
- Typical schedule: Once weekly
- Cycle length: Open-ended, titrate over months
References
- Mazdutide in Chinese adults with obesity (Phase 3) — Ji L et al., Nat Med, 2025
- Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight (GLORY-1) — Ji et al., N Engl J Med, 2025
- A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity — Ji et al., Nature Communications, 2023
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.