What are the side effects of Mazdutide?
The most commonly reported Mazdutide side effects are nausea, constipation or diarrhea, mild fatigue. Most are mild and tend to be dose dependent. It is generally avoided with mTC / MEN-2 history. Human clinical evidence for Mazdutide is limited, so this reflects reported and observed effects, not a complete safety profile.
Reported Mazdutide side effects
- Nausea
- Constipation or diarrhea
- Mild fatigue
- Slightly elevated heart rate (glucagon effect)
Who should avoid it
- MTC / MEN-2 history
- Pancreatitis history
- Pregnancy / nursing
Bloodwork worth tracking
- Lipid panel
- ALT/AST
- A1C
References
- Mazdutide in Chinese adults with obesity (Phase 3) — Ji L et al., Nat Med, 2025
- Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight (GLORY-1) — Ji et al., N Engl J Med, 2025
- A phase 2 randomised controlled trial of mazdutide in Chinese overweight adults or adults with obesity — Ji et al., Nature Communications, 2023
Pepdex is an editorial reference, not medical advice. Peptides vary in legal and approval status by country, many are research compounds without full human safety data. Talk to a qualified clinician before starting anything.
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Last updated 2026-06-06.