pepdex
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№ 014

Sermorelin

GHRH analog, the older sibling to Tesamorelin and CJC. Restores natural GH pulses, gentler profile.

GH-axis
Evidence: Moderate
Half-life
~10-20 minutes
Route
Subcutaneous
Cycle
12-24 weeks
Schedule
Once daily, typically before bed
In plain English

Sermorelin is the older, gentler cousin in the GH-axis family. Approved decades ago. Often used by anti-aging clinics for adults with declining GH output. Daily injection at bedtime.

Status & legality
Natty?
Not natty
FDA
Not approved

Originally approved as Geref (1997) as a pediatric GH-deficiency diagnostic, later withdrawn from the market.

Compounding
Not classified

Not formally categorized in the FDA bulks lists.

WADA
Banned (S2)
Prescribed

Some longevity / anti-aging clinics prescribe via compounding pharmacies, off-label.

Who it's for

  • →Beginners to GH-axis peptides
  • →Older adults with declining GH output
  • →Users wanting a gentle, sustainable GH support tool

What to expect

  1. Week 1

    Sleep deepens. Vivid dreams.

  2. Week 4

    Recovery improvements. IGF-1 climbing modestly.

  3. Week 8

    Body comp and skin changes for users in a clean diet.

Dosing protocol

200-500 mcg sub-q nightly, on an empty stomach. Some protocols use 100-300 mcg twice daily.

Stacks well with

Ipamorelin for synergistic GH pulse
GHK-Cu for skin / connective-tissue support

Side effects

01Head-rush at injection
02Hunger pulse 30-60 min post-dose
03Mild flushing

When NOT to use

  • ⚠Active malignancy
  • ⚠Pituitary disorders
  • ⚠Pregnancy / nursing

Bloodwork to monitor

  • • IGF-1 baseline + week 8

Common mistakes

  • • Eating within 30 min of injection (food blunts the GH pulse)
  • • Underdosing — sub-200mcg often produces no measurable change
  • • Skipping the cycle break

Educational only. User-specific dosing is between you and a qualified provider.

Frequently asked

What is Sermorelin?+
Sermorelin is the older, gentler cousin in the GH-axis family. Approved decades ago. Often used by anti-aging clinics for adults with declining GH output. Daily injection at bedtime.
Is Sermorelin FDA approved?+
Originally approved as Geref (1997) as a pediatric GH-deficiency diagnostic, later withdrawn from the market.
Is Sermorelin banned by WADA?+
Sermorelin is on the WADA prohibited list under Banned (S2).
Are you still natty after taking Sermorelin?+
No. Sermorelin is a performance-enhancing peptide and would disqualify a strict natty claim.
Do doctors prescribe Sermorelin?+
Some longevity / anti-aging clinics prescribe via compounding pharmacies, off-label.
What's the typical dose of Sermorelin?+
200-500 mcg sub-q nightly, on an empty stomach. Some protocols use 100-300 mcg twice daily.
What are the side effects of Sermorelin?+
Common side effects include: Head-rush at injection; Hunger pulse 30-60 min post-dose; Mild flushing. Less common effects and full safety details are on the entry page.
How long until Sermorelin starts working?+
Sleep deepens. Vivid dreams.