Independent & opinionated
The Honest Peptide Report Card
The peptides with the loudest reputations often have the quietest evidence. Of the most-talked-about compounds, the majority sit on limited or anecdotal data, while several of the strongest-evidence peptides barely get mentioned. Here is the honest grade for each, from an independent resource that sells nothing.
Most overhyped
Loud reputation, thin evidence.
- BPC-157Limited evidence
- IpamorelinLimited evidence
- MT-2 (Melanotan II)Limited evidence
- TB-500Limited evidence
- CJC-1295 (no DAC)Limited evidence
- IGF-1 LR3Limited evidence
Most underrated
Strong evidence, barely any buzz.
- TeriparatideStrong evidence
- Octreotide (Sandostatin)Strong evidence
- Setmelanotide (Imcivree)Strong evidence
- Pramlintide (Symlin)Strong evidence
- Teduglutide (Gattex / Revestive)Strong evidence
- SermorelinModerate evidence
Grades reflect the strength of published research, not a recommendation to use or avoid anything. See how we rate evidence. This is information, not medical advice.
The full report card
| Peptide | Evidence | The honest verdict |
|---|---|---|
| BPC-157 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Tirzepatide | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Semaglutide | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Retatrutide | Moderate | Some real human data, but not a sure thing yet. |
| HGH (Somatropin) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| MK-677 (Ibutamoren) | Moderate | Some real human data, but not a sure thing yet. |
| HCG (Human Chorionic Gonadotropin) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| PT-141 (Bremelanotide) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Liraglutide (Saxenda / Victoza) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Ipamorelin | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| MT-2 (Melanotan II) | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| TB-500 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| CJC-1295 (no DAC) | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| IGF-1 LR3 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Cagrilintide | Moderate | Some real human data, but not a sure thing yet. |
| Oxytocin | Strong | Proven. An approved drug with real human data. The hype is earned. |
| GHK-Cu | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| HGH Fragment 176-191 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| GHRP-2 / GHRP-6 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Follistatin 344 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Cerebrolysin | Moderate | Some real human data, but not a sure thing yet. |
| VK2735 | Moderate | Some real human data, but not a sure thing yet. |
| MT-1 (Melanotan I) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Tesamorelin | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Survodutide | Moderate | Some real human data, but not a sure thing yet. |
| Semax | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Mazdutide | Moderate | Some real human data, but not a sure thing yet. |
| IGF-1 DES | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Dihexa | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Amycretin | Moderate | Some real human data, but not a sure thing yet. |
| Sermorelin | Moderate | Some real human data, but not a sure thing yet. |
| MOTS-c | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Hexarelin | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Thymosin Alpha-1 (Tα1) | Moderate | Some real human data, but not a sure thing yet. |
| Kisspeptin-10 | Moderate | Some real human data, but not a sure thing yet. |
| LL-37 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Teriparatide | Strong | Proven. An approved drug with real human data. The hype is earned. |
| PEG-MGF | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Octreotide (Sandostatin) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Petrelintide | Moderate | Some real human data, but not a sure thing yet. |
| Epitalon | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| DSIP | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| SS-31 (Elamipretide / MTP-131) | Moderate | Some real human data, but not a sure thing yet. |
| VIP (Vasoactive Intestinal Peptide) | Moderate | Some real human data, but not a sure thing yet. |
| Setmelanotide (Imcivree) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Pemvidutide | Moderate | Some real human data, but not a sure thing yet. |
| Selank | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| AOD-9604 | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| MGF (Mechano Growth Factor) | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Pramlintide (Symlin) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| 5-Amino-1MQ | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| KPV | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Pinealon | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Humanin | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| ARA-290 (Cibinetide) | Moderate | Some real human data, but not a sure thing yet. |
| ACE-031 (ACVR2B-Fc) | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| FOXO4-DRI | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| Teduglutide (Gattex / Revestive) | Strong | Proven. An approved drug with real human data. The hype is earned. |
| Thymalin | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| Russian Bioregulators (overview) | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| AHK-Cu | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| SNAP-8 (Acetyl Octapeptide-3) | Limited | Thin evidence. Mostly early or animal data, a lot of anecdote. |
| PE-22-28 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| PNC-27 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| B7-33 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| DNSP-11 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| FGL | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
| P-21 | Anecdotal | Hype outpacing proof. Big reputation, almost no human evidence. |
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